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In individuals with obesity, excess fat can lead to: Altered sex hormone levels : Increased aromatisation of androgens to oestrogens in adipose tissue, potentially affecting testosterone levels in both men and women [14] Insulin resistance : Which may impair endothelial function and reduce blood flow necessary for sexual arousal Elevated inflammatory markers : Chronic low-grade inflammation associated with obesity can negatively impact vascular and sexual health As weight decreases, these parameters often improve
A Phase 2 trial (a mid-stage human trial, typically involving a few hundred participants) published in the New England Journal of Medicine in 2023 reported an average weight loss of about 24% at 48 weeks with the highest dose
At Regen Wellness , we are moving beyond the simple math of calories and into the sophisticated science of Biological Signaling
Theres no rationale to try micro-dosing, Cleek said
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