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Predrag Sikiric, the principal investigator behind the majority of BPC-157 research, has described the peptide's vascular effects as "maintaining the balance between NO-system components rather than simply upregulating NO production" [4]
The actin-binding region itself has been linked to vascular activity: a 2003 study in the FASEB Journal reported that the site promoting actin interaction is also associated with angiogenic activity in experimental models
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