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To minimise problems: Sip water regularly and aim for around 2 to 3 litres per day, unless your doctor advises otherwise Consider water rich foods such as soups, cucumbers and watermelon Start with smaller meals, eating slowly and stopping at the first sign of comfortable fullness Focus on softer, easy to digest foods if you feel unwell 4
Every person's body and lifestyle are different, so there will always be some fluctuations in the time frame you can expect medications to take effect
Peer review Peer review information Nature Chemistry thanks Daniel Reker and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
Trials have typically used titration periods of about 6 weeks, starting at a lower dose and stepping up to the full maintenance dose
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