Activated microglia produce ROS and pro-inflammatory cytokines, contributing to the oxidative and inflammatory environment in the PD brain
Funding This study was supported by grants from the National Natural Science Foundation of China (82302925, 82272702), Natural Science Foundation of Zhejiang Province (LQ23H160012, LZ23H160001, LTGY23H080005), the project of Science and Technology Plan of Traditional Chinese Medicine of Zhejiang Province (2024ZL1010), Wenzhou Science and Technology Bureau of China (ZY2023021), and in part supported by the Key Discipline of Zhejiang Province in Medical Technology (First Class, Category A)
The intracellular concentrations of vitamin B12 can be inferred through the total plasma concentration of homocysteine, which can be converted to methionine through an enzymatic reaction that uses 5-methyltetrahydrofolate as the methyl donor group
449 Notably, a dosage of 10 mg/kg/day of methazolamide significantly improved these parameters, exhibiting similar efficacy to 30 mg/kg/day of acetazolamide