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Genetic factors affecting receptor expression or downstream signaling may limit effectiveness
2007: A study in 36 people (average age 63) with coronary artery disease found that taking 500 mg of acetyl-L-carnitine plus 200 mg of alpha-lipoic acid twice daily for 8 weeks lowered systolic blood pressure by 9 mmHg in those with coronary artery disease and high blood pressure, which was significant compared to placebo
This finding emerged from a comprehensive bioinformatics analysis that evaluated the SLC-associated glutamine transporter proteins in the context of breast cancer patient prognosis
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