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Activated microglia produced inflammatory mediators, such as prostaglandin E 2 , interleukin-1 TNF, ROS (peroxideH 2 O 2 , superoxideO 2 ), and reactive species nitrogenous (RNS: NO

Summary: Patients with sulphonamide allergy must avoid all sulphonamide antibiotics (such as co-trimoxazole, sulfadiazine, and sulfamethoxazole), whilst non-antibiotic sulphonamides require individualised risk assessment as immunological cross-reactivity is unlikely but some products remain contraindicated

What to Expect Timeline: Many patients start to notice improvements within a few weeks of beginning treatment

Orrenius et al., 2007)