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Safer Alternatives and Evidence-Based Treatment Options MHRA-licensed options including semaglutide (Wegovy), liraglutide (Saxenda), orlistat, and tirzepatide (Mounjaro) offer evidence-based weight management with well-characterised safety profiles and defined NICE eligibility criteria
Johnson BV et al
The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For
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