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The Journal of endocrinology
As for the mechanisms of hypotensive effect beyond BW, augmentation of natriuresis by inhibiting sodium hydrogen exchanger at proximal tubule, ameliorating angiotensin II activity, and enhancing vasodilation can be postulated
The tradeoffs are real: lower cost in exchange for less regulatory certainty about the finished product
For other areas, ensure adequate subcutaneous tissue exists for safe injection
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