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Tao, & Y
Curated data place Melanotan 1 as a full agonist at four subtypes with a clear order-of-magnitude preference for MC1R: pIC 10.0 at MC1R, pKi 8.9 at MC3R, pKi 8.5 to 8.8 at MC4R, pIC 9.0 at MC5R, and no activity at MC2R
Presented for research literature review only Fukushima N et al
It has been shown to inhibit melanin production which in turn helps lighten dark spots, age spots, and hyperpigmentation promoting an even skin tone
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