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The SURPASS-CVOT trial (NCT04255433) will assess the cardiovascular safety of tirzepatide compared to dulaglutide in people with T2D and established atherosclerotic disease [111]

Medical guidance is safer than self-administering research chemicals

Although no significant differences were initially observed between the groups after 3 months, the use of the gel resulted in an 85% disease resolution rate, compared with a 70% resolution rate without adjunctive application of the gel (Reference Iorio-Siciliano, Marasca and Mauriello104)

Studies have examined the relationship between NNMT inhibition and cellular NAD+ levels, which are critical for numerous enzymatic reactions including those involving sirtuins and PARPs