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Also in CLL, most recent interim results of a Phase II study evaluating GS-9973, an investigational oral inhibitor of spleen tyrosine kinase (Syk), achieved an overall response rate of 49%, with an estimated progression-free survival rate of 70%, and 62% of patients achieved at least a 50% tumor reduction

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In the pancreas, GLP-1 stimulates the release of insulin, increases the amount of insulin-producing pancreatic cells (beta cells) and reduces the release of glucagon a hormone that raises blood sugar levels

A major concern in the treatment of patients with T2DM is to identify a therapeutic agent that can prevent the gradual declines in -cell function and mass