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4 : 0.3), excellent microsomal stability, negligible CYP inhibition, and minimal P-gp efflux, yielding robust CNS penetration (Chino et al., 2018)

While not yet FDA-approved as a standalone agent, cagrilintide peptide therapy is being investigated for: Obesity treatment Metabolic syndrome management Adjunctive therapy for GLP-1 agonist non-responders Research in combination with emerging agents like retatrutide Note: As of 2025, cagrilintide is still considered a research compound in many jurisdictions

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Du S, et al