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McClean et al
Pregnancy makes this vivid
A third incretin-based approach is tirzepatide, a dual agonist of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR), which achieves greater HbA1c reduction and weight loss compared with GLP-1RAs alone
Subsequent research demonstrated that loss of orexin function results in a condition in animals that mimics the sleep disorder in humans known as narcolepsy
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