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Researchers using lyophilized vs liquid peptides should be aware that reconstituted lyophilized peptides have different storage requirements and may require refrigeration immediately after reconstitution

Given the observed hydrogen-bonding interactions with Q726 and Y524 and considering the contribution of the P-clamp region to PDE10A selectivity, future optimization should prioritize (i) enhancing potency by incorporating structural constraints that properly orient key substituents to reinforce the Q726/Y524 hydrogen-bond network and (ii) modulating lipophilicity and polar surface area to achieve an optimal balance between CNS penetration and effective P-clamp engagement

It's not uncommon, especially when first starting, to notice a small, localized reaction at the injection site