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The decision to wean or stop abruptly should be individualized based on several factors: Reason for discontinuation : Side effects, cost, achievement of weight goals, or medical contraindications Duration of treatment : Longer treatment periods may benefit from gradual transition Weight loss achieved : Greater weight loss may require more structured discontinuation planning Presence of comorbidities : Diabetes or cardiovascular conditions may need closer monitoring Patient preference and psychological readiness : Some individuals prefer gradual adjustment While not medically necessary, a stepwise reduction over 4-8 weeks allows patients to implement behavioral strategies, adjust dietary habits, and psychologically prepare for the metabolic changes that follow discontinuation

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(A) Synthesis of the endocannabinoid system (ECs) and enzymes enrolled in endocannabinoid hydrolysis in neurons

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