Similarly, in the pathogenesis of MS, peripheral immune cells penetrate the BBB into the brain and destroy myelin membranes and neurons (Sweeney et al
157 For example, MRP1 mediates resistance to methotrexate, cisplatin, and vinca alkaloids and is frequently overexpressed in lung, ovarian, and hematologic malignancies
Severe deficiencies, especially those with neurological symptoms (numbness, tingling, memory issues), often require a more intensive initial treatment plan to rapidly restore healthy B12 levels and prevent lasting nerve damage
Therefore, it is especially important to supplement with effective glutathione if you must be on one or more of these drugs