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Avoid higher doses because you run the risk of greater side effects without any proven benefits
In the study performed in 2024 the total concentration of regorafenib and its metabolites in hypoalbuminemic patients was determined to be below target plasma concentration ranges, what may contributed to shorter overall survival in the hypoalbuminemic group of patients
These studies are mechanistically aligned with the VEGFR2/eNOS in vitro findings but rely on the same originating laboratory and rodent model system, and independent replication outside that network is sparse
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