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The Billon 2025 paper (PMID 41421047) is the citation that anchors the route question: SLU-PP-915 was developed because SLU-PP-332 "lacks oral bioavailability." If the parent compound does not absorb orally, oral capsules and tablets are unlikely to produce the systemic ERR agonism seen in mice

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ASA Guidance on Preoperative Management of GLP-1-RA Use In June 2023, the ASA released guidance on withholding GLP-1-RA to reduce aspiration risk based on anecdotal reports

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The absolute risk increase for diabetic retinopathy complications was larger among patients with a history of diabetic retinopathy at baseline (semaglutide injection 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide injection 0.7%, placebo 0.4%)

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Untreated vitamin b12 deficiency can lead to serious health consequences, physical, neurological, and even mental health issues like anxiety or depression

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