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Mechanistically, these variants influence the expression of neighboring regulatory genes such as IRX3 and IRX5 , which are responsible for the differentiation of adipocytes from energy-consuming beige cells to energy-storing white fatty cells, alongside reducing mitochondrial thermogenesis and promoting lipid accumulation

The article says sertraline can cause nausea, appetite changes and mild diarrhea or constipation, while semaglutide commonly reduces appetite and may cause nausea, constipation or diarrhea

TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation

Moreover, metformin can directly protect endothelial cells from injury, which is beyond its glucose-lowering effects 7,8