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While some studies identify DGF as an independent risk factor ( Other Modifiable Factors: Diuretic Use: A prospective cohort study found a 3.28-fold increased hazard for PTDM associated with diuretic use ( Dyslipidemia: Elevated remnant lipoprotein (RLP) cholesterol is a novel, independent predictor of PTDM ( Metabolic Syndrome: Pre-transplant metabolic syndrome significantly increases PTDM risk ( Visceral Adiposity: Visceral adipose tissue volume correlates more strongly with PTDM than BMI alone ( HLA Mismatch: Evidence remains conflicting ( 5 Diagnosis and challenges Accurate diagnosis of PTDM is essential but presents several challenges

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Comprehensive studies have demonstrated a central role for inflammation in motor neuron degeneration and death in ALS