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Furthermore, studies have reported an aberrant activation of NRF2, a key antioxidant transcription factor involved in the regulation of critical antioxidants including glutathione, SOD, and CAT, leading to reduced antioxidant capacity (Hirayama et al., 2020)
Driven by the IRhyperinsulinemiahyperandrogenism axis, metabolic imbalance directly disrupts follicular development, leading to chronic ovulatory dysfunction and deteriorating both oocyte quality and endometrial receptivity (21, 22)
However, most people find that lower doses of high-bioavailability formulas provide the same support without the risk of digestive upset
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