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usually most pronounced during dose escalation Diarrhea : Affects 12-17% of patients, typically mild to moderate in severity Vomiting : Reported in 6-10% of patients, more common at higher doses Constipation : Occurs in 6-11% of patients Abdominal pain and dyspepsia : Generally transient Decreased appetite : An expected pharmacological effect contributing to weight loss Other documented adverse effects include injection site reactions, hypoglycemia (when used with insulin or sulfonylureas), and less commonly, fatigue

Research progress on oral glucagon-like peptide-1 receptor agonists in the treatment of diabetes mellitus type 2

We do not yet have clear answers on: Long-term safety Optimal dosing strategies Metabolic interactions Effects on weight loss outcomes Some patients who stop GLP-1 treatment may see lost weight return over time

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