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A 2025 narrative review published in Frontiers in Clinical Diabetes and Healthcare analyzed the existing body of research on GLP-1 receptor agonists and exercise

[6] [7] The fundamental mechanism involves binding to GLP-1 receptors located throughout the body, particularly in pancreatic beta cells, the gastrointestinal tract, and the central nervous system

This means that these patients did not achieve enough weight loss to provide them benefit in risk reduction for obesity associated conditions like diabetes and heart disease, while using [a] GLP-1 therapy alone

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