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The insulin/IGF system in colorectal cancer development and resistance to therapy

10.1186/s12943-015-0490-2 42

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NHS Wegovy provision is governed by NICE guidance (TA875), which recommends semaglutide 2.4 mg as an option for weight management in adults with: A body mass index (BMI) of at least 35 kg/m and at least one weight-related comorbidity (such as hypertension, type 2 diabetes, obstructive sleep apnoea, or cardiovascular disease), or A BMI of 30.034.9 kg/m who meet specialist service referral criteria For people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean family backgrounds, BMI thresholds are typically reduced by 2.5 kg/m due to higher health risks at lower BMI levels