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This interesting finding, occurring without weight loss, is consistent with preclinical and clinical studies showing weight-independent effects of GLP-1R agonism on liver steatosis 51,52,53
Ever since SGLT2is and GLP1RAs demonstrated cardiovascular benefits in cardiovascular outcome trials (CVOTs), studies have attempted to elucidate the mechanisms of these drugs in reducing cardiovascular events
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Although the most commonly reported adverse events were gastrointestinal side effects such as nausea, vomiting, and diarrhoea, the treatment was well tolerated in the study population [59, 60]
