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In two cases report of systemic amyloid A amyloidosis and advanced CKD tocilizumab administration lead to rapid resolution of the nephrotic and inflammatory state with de-intensification of the dialysis regimen and cessation of erythropoietin [134, 135]
This is particularly connected to newer combined GLP-1-GIP medication tirzepatide (Zepbound), which may reduce the absorption of oral contraceptives into the system
A variant in the GLP1R gene is associated with differences in weight loss, while a variant in the GIPR gene predicts nausea specifically in people taking tirzepatide (Mounjaro), not semaglutide (Wegovy or Ozempic)
For background, see the FDA Federal Register determination on Geref (sermorelin acetate)
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