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3PO inhibits inflammatory NFkappaB and stress-activated kinase signaling in primary human endothelial cells independently of its target PFKFB3

As an example, GSTZ1-1 catalyzes the cis-trans isomerization of 4-maleylacetoacetate to 4-fumarylacetoacetate within the phenylalanine catabolic pathway 21

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[118] The tentative approval means that a scientific assessment of the generic drug was completed successfully, and that contracts and supply chains can be established, but that selling the drug would depend on intellectual property constraints