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8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs

Vitamin B12 has a long history of effective subcutaneous delivery, with little to no muscle pain after B12 injections

Improves Mood & Reduces Stress B12 contributes to serotonin production, improving mood and helping to manage stress

By helping to increase the production of red blood cells, vitamin B12 may improve oxygen delivery to the muscles during exercise