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There's no strong evidence of receptor desensitization with continuous use, but periodic breaks remain standard practice in most clinical protocols
People who have severe gastrointestinal conditions like inflammatory bowel disease (IBD) or gastroparesis should not go on GLP-1s, and neither should people with a personal or family history of multiple endocrine neoplasia 2A, multiple endocrine neoplasia 2B, medullary thyroid cancer, or pancreatitis
Consult professionals before trying any new therapy
Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus
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