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When compared to pre-surgery, GLP-1R antagonist administration more significantly increased activation in the caudate nucleus to visual food cues and in the insula to gustatory food cues after RYGB, indicating an effect of surgery on the actions of GLP-1R blockage (Jennifer et al., 2017)

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Additionally, a single molecule tri-agonist of GLP-1R, GIPR and GCGR can increase insulin secretion and improve blood glucose handling in mice beyond the cumulative effects of the three individual agonists separately ( 2+ mobilisation observed in human clonal pancreatic beta cells