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This applies to the cumulative time out of refrigeration, even if the pen is returned to the refrigerator during this period

Temperature proves most critical - every 10C increase doubles degradation rate, meaning room temperature storage (25C) degrades peptides 4-8x faster than refrigeration (2-8C) and dramatically faster than freezing (-20C or below)

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It is now available via Ozzis website to US consumers, with all purchases including guidance for use as part of a broader evening routine.