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Secondly, multiple tumor types have been reported to harbor an intratumoral microbiome, where local bacterial cells and their microbe-associated molecular patterns (MAMPs) shape the TME through TLR/nucleotide-binding oligomerization domain (NOD) and other axes, affecting treatment sensitivity and even directly metabolizing chemotherapy drugs (such as gemcitabine) [38]
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They use blood tests to check Vitamin B12 levels
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