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To test whether the regulation of CYP8B1 by T3 would have any effect on BA composition, we performed UFLC-Triple-time of flight/MS-based metabolite profiling to quantitate the BA levels and found that the percentage of 12-hydroxylated (12-OH) BAs was reduced, while the proportion of non-12-hydroxylated (non-12-OH) BAs was increased in the gallbladder bile, ileum, liver, serum, and urine after five days of T3 treatment in MMI mice (Fig
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Its peptide structure is entirely different from the small-molecule drugs targeted by immunoassay tests, with no known cross-reactivity
Cognitive effects could possibly depend on baseline nutritional status, i.e., any benefits of micronutrient supplementation might only be realized in individuals with micronutrient deficiencies and not in those with adequate micronutrient status
