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Typical diet and lifestyle modification strategies achieve around 5% weight loss, but maintenance of weight loss is often unsuccessful, with a return to baseline within 25 years (4,13,14)
This was also before approved indications like sleep apnea were added for GLP-1s such as tirzepatide and semaglutide
No participants in any clinical trial developed detectable anti-AOD9604 antibodies, even after 24 weeks of continuous exposure
This is not surprising because GLP-1 medications "inhibit dopamine release in the brain's reward center" (Laurindo, 2022)
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