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As the placebo group continued to have an increasing (worsening) motor score over time, the exenatide-treated group demonstrated improvements, which remarkably remained after the treatment had been stopped for 3 months (weeks 48-60 on the graph below)
Some clinicians and researchers explore split semaglutide dosing twice weekly or split tirzepatide dosing as a way to maintain more consistent blood levels and potentially improve results while reducing peak-dose side effects
Efficacy vs
Ozempic, licensed for type 2 diabetes) and liraglutide (Saxenda, licensed for weight management)
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