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A comprehensive review of Wnt/PCP can be found in a recent review by Ezan and Montcouquiol (Ezan and Montcouquiol, R-spondins and Lgr receptors An important group of ligands and receptors in stem cell biology and regeneration, the R-spondin family of ligands and leucine rich repeat (Lgr) G-coupled family of receptors, was recently linked to Wnt signaling (Jin and Yoon, 2012)