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Dental caries is a pH-mediated bacterial disease that affects the hard surfaces of the teeth, making the oral environment a critical factor in maintaining tooth integrity
We used the method of CCK8 to determine the concentration of PA, berberine and GLP-1 (9-36) amide in STC-1 cells (Figure 6A)
Overall, we conclude that PC patients with low expression of VRK2 are sensitive to GSH-targeting therapy, while PC patients with high expression of VRK2 are re-sensitive to GSH-targeting therapy following VRK2 inhibition, indicating genetic aberrance of VRK2 expression stratifies the response of PC to metabolism-targeted therapies
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