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17 Similarly, in a meta-analysis of 14 RCTs in T2DM patients conducted by Liu et al, tirzepatide was shown to provide superior HbA1c reduction and improved metabolic outcomes compared to placebo, insulin, and all other GLP-1 RAs at all doses examined

The 2023 phase 2 double-blind, randomized controlled trial evaluating a GLP-1/GIP/glucagon receptor triagonist (retatrutide) in patients with the disease of obesity reported 24.2% weight loss at 48 weeks with 12 mg retatrutide

Nikiteas NI, Tzanakis N, Gazouli M, Rallis G, Daniilidis K, Theodoropoulos G et al

PET/CT scans have shown that females tend to have higher detection rates and greater amounts of BAT compared to males [27]