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11.5 Pharmacokinetics and bioavailability It is evident that following oral administration, resveratrol is rapidly absorbed in the gastrointestinal tract (75%) with an extensive first-pass metabolism in the intestine and liver, lowering its oral bioavailability (ranging from 2.6 to 75% in humans and 2029% in rats fed 50 mg/kg) [198]

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3.1.2 Acute Lung Injury ALI and its severe form, acute respiratory distress syndrome (ARDS), are common respiratory critical syndromes with no effective therapeutic intervention

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