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The results, which were published in the Lancet on Thursday, are very encouraging for the safety and efficacy of orforglipron in people with type 2 diabetes, says Daniel Drucker, an endocrinologist at the University of Toronto, adding that he is awaiting further clinical trial results of the drug in people with obesity

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Yet, alterations in EEC numbers and secretion of gut hormones have also been observed in intestinal inflammation and were implicated in the changes in feeding patterns often accompanying these conditions (146, 147) (Figure 4)