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The iron overload-induced oocyte damage and embryo toxicity might be related to ferroptosis mediated by multiple signaling pathways, including nuclear receptor coactivator 4-dependent ferritinophagy (123), glutathione peroxidase 4-dependent downregulation (124), and heme oxygenase 1 (HMOX1) overexpression (120), in which mitochondrial dysfunction and structural damage play a central role

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Innovation : The current AOM pipeline comprises 157 clinical-stage assets, including 7 in phase 3, and spans over 60 mechanisms of action, while 43% of all AOM assets are oral therapies (see Figure 2)