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Long-term vitamin B12 deficiency of greater than 3 months may result in irreversible degenerative lesions of the spinal cord (CNS)
Storing a vial on its side or inverted keeps the solution in sustained contact with the rubber stopper, which pharmaceutical literature describes as a potential leachable-contamination pathway over extended periods
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The same technique applies when you [reconstitute tirzepatide](/guides/how-to-reconstitute-tirzepatide-mixing-guide)
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