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As with all GLP-1 receptor agonists, there are class-level safety considerations to be aware of, based on UK Summary of Product Characteristics (SmPC) for approved agents such as semaglutide (Wegovy): Pancreatitis : If pancreatitis is suspected indicated by severe, persistent abdominal pain, which may radiate to the back treatment should be stopped immediately and urgent medical assessment sought
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concluded that the most effective targets of action were PPARA, SHBG, AKR1B1, PPARG, IGF1R, MMP9, AKT1, and INSR structural domains after network pharmacology intersecting the drug targets of RES with disease targets
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