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125,126,127 The antiviral drug ganciclovir has been shown to improve the intestinal inflammatory response and intestinal mucosal injury in UC mice by inhibiting STING activity in macrophages
According to the UK SmPC, the most frequently reported adverse effects include: Gastrointestinal side effects (very common, affecting more than 1 in 10 people): Nausea often most pronounced during the initial weeks of treatment or following dose escalation Diarrhoea may be mild to moderate and typically improves with continued use Vomiting can occur, particularly if dietary modifications are not made Constipation less common than diarrhoea but reported in some patients Abdominal pain or discomfort usually transient Decreased appetite a therapeutic effect contributing to weight loss but may be troublesome for some These gastrointestinal symptoms are generally dose-dependent and tend to diminish over time as the body adapts to the medication
Increase vitamin C intake through fruits and vegetables, over-the-counter supplements, or as advised by a doctor to help prevent gout
