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66,67 Therefore, contribution to cyclosporine nephro- and hepatotoxicity has been postulated to be caused by its generation of free radicals and depletion of GSH

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Taken together, these results indicate that OsDHAR has potent chaperone-like properties and is capable of protecting proteins from precipitation and heat-induced loss of enzymatic activity, suggesting that OsDHAR is a potent inhibitor of stress-induced protein aggregation

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