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Utilities and disutilities associated with complications, including overweight, in the model are calculated based on corresponding HRQoL values identified in a review of utility values for economic modelling in type 2 diabetes [47,48,49,50,51], and disutilities associated with serious and non-serious hypoglycaemia events identified in a report [52] which was published after the main review article (Appendix Table 12)

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These abnormally large red blood cells, known as megaloblasts, simply can't carry oxygen as efficiently as healthy, normal-sized ones