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Abdominal pain, particularly if severe, persistent, or radiating to the back, may indicate pancreatitisa rare but serious adverse effect requiring emergency evaluation

Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut Saccharomyces boulardii: What Makes It Tick as Successful Probiotic

Importantly, while folic acid successfully decreases these toxicities, it does not alter or compromise the clinical efficacy of low-dose methotrexate in controlling joint inflammation and disease activity parameters (Friedman & Cronstein, 2019)

This can be convenient for patients on higher maintenance doses because each injection requires less liquid