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Following an acute administration of EtOH (5 g/kg, i.p.), KO animals exhibited 30% and 50% less EtOH and AA accumulation in circulation, respectively, suggesting an increased capacity for liver EtOH and AA metabolism in KO mice

This provides a foundation for conducting clinical trials in humans to explore the efficacy of GLP-1RAs in treating IBD patients, particularly in populations with metabolic disorders [226]