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These dual agonists were found to reduce blood sugar and increase insulin secretion in mice, monkeys, and humans.27 Subsequently, they investigated a triple agonist capable of simultaneously targeting the GLP-1R, the GCGR, and the GIPR

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In adults with obesity who achieved weight loss on a low-calorie diet, adding liraglutide, a GLP-1 receptor agonist, plus regular moderate-to-vigorous exercise for one year further lowered metabolic syndrome severity and abdominal fat

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Individual needs may vary, as well as the side effects

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