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This approach, borrowed from tirzepatide trials, proved effective at improving tolerability

Methods Study design and procedures This was a phase 1, randomised, placebo-controlled, double-blind, combined single ascending dose (Part A) and multiple ascending dose (Part B) study conducted in overweight or obese participants with type 2 diabetes (ClinicalTrials.gov registration no

When you go off the drugs and then take them again, youre more likely to experience the gastrointestinal side effects again, she says, noting that these tend to lessen as you get used to the medication